Data Mining of Enzymes (DME)
The method of Data Mining of Enzymes is described in detail in the article
Data mining of enzymes using specific peptides.
(Uri Weingart, Yair Lavi and David Horn) BMC Bioinformatics 2009, 10:446
It is based on the Specific Peptide (SP) approach developed in the paper
representation of enzymes by specific peptides
(Vered Kunik, Yasmine Meroz, Zach Solan, Ben Sandbank, Uri Weingart,
Eytan Ruppin and David Horn)
PLOS Computational Biology 2007, 3(8):e167.
The appearance of SPs, deterministic motifs of amino-acids, on the sequence of a putative protein indicates that the sequence
belongs to an enzyme, and specifies its EC categorization.
DME11 is a webtool providing all SP hits on a protein query,
including also indicators of active and binding sites, protein families and domains, all extracted from
Swiss-Prot training data.